Lucille Elizabeth Bush was a Montgomery County, Kentucky, native, the daughter of a prominent Mount Sterling physician. She was a graduate of the University of Kentucky and by the 1920s was exhibiting her art. She appeared in the 1925 Nashville (Tennessee) Art Association show of Kentucky artists, sharing wall space with Bruce Vance, Patty Thum, Charles Courtney Curran, John Doll, Frederick Weygold, Evelyn Scales Mercke and many others. That same year she took an art position in Minnesota.

From 1930 until at least 1945 she was an art instructor at Skidmore College in Saratoga Springs, New York. In 1945 she received an American Association of University Women fellowship and in 1947 traveled to Italy to study Renaissance art. She held a graduate degree from Columbia University, New York City. Information about her life in the last half of the 20th century is scarce. She died in Columbus, Georgia, and is buried in Mount Sterling.